葡萄糖酸锌颗粒与四君子汤加味联合治疗小儿反复呼吸道感染临床分析

A Clinical Analysis of Treating Reoccurring Respiratory Tract Infection in Children by Combining Zinc Gluconate Granula and Decoction of Four Mild Drugs

目的研究葡萄糖酸锌颗粒、四君子汤加味联合治疗小儿反复呼吸道感染(RRI)的临床疗效及免疫指标的变化。方法将135例RRI患儿随机分为治疗组和对照组,对照组67例予西医常规抗感染及对症治疗,治疗组68例在此基础上加服葡萄糖酸锌颗粒、四君子汤加味治疗8周,随访3个月,比较两组总疗效和治疗前后IgG、IgA、IgM的变化。结果治疗组68例,显效48例,有效15例,无效5例,总有效率92.64%;对照组67例,显效33例,有效10例,无效24例,总有效率64.18%。两组比较,治疗组疗效优于对照组(P<0.01)。治疗组治疗后RRI发作次数明显减少,血清IgG、IgA、IgM水平较前明显提高。结论葡萄糖酸锌颗粒与四君子汤加味联合应用能提高患儿免疫功能,治疗RRI有显著疗效。

Objective To study the clinical effects and changes in immune index of treating reoccurring respiratory tract infection in children by combining zinc gluconate granula and decoction of four mild drugs. Methods 135 RRI children patients were randomly divid- ed into treatment group which has 68 cases and control group which has 67 cases. The control group are given regular western anti - infection treatment while the treatment group are given, in addition to that, zinc gluconate granule and decoction of four mild drug. Both groups are observed for 3months and then compare the effects and changes of IgG,IgA,IgM before and after the treatment. Results 48 out of 68 cases in treatment group have results of excellence,15 cascs have effects and 5 cases show no effects, so the effective rate is 92.64% ; While 33 out of 67 cases in control group have results of excellence,10 cases have effects and 24 cases show no effects, so the effective rate is 64.18%. Comparing these two groups, the treatment group gets better effects than the control group （P 〈 0.01 ）. After the treatment there are fewer times of RRI breakouts in the treatment group and levels of blood serum IgG,IgA,IgM are much higher. Conclusion Combining zinc gluconate granula and decotion of four mild drugs can improve the immune function in children patients and have outstanding curative effects in treating RRI.