妊娠肝内胆汁淤积症患者总胆汁酸水平与胎儿宫内窘迫关系的探讨

Study About the Relationship Between the Level of Serum Total Bile Acid and Fetal Distress of Intrahepatic Cholestasis Pregnancy

目的探讨妊娠肝内胆汁淤积症(ICP)患者总胆汁酸(TBA)水平与胎儿宫内窘迫关系。方法将357例ICP患者分非胎儿宫内窘迫组和胎儿宫内窘迫组,对两组总胆汁酸水平回顾性分析探讨。结果胎儿宫内窘迫的发生率随TBA值的增加而增加,当TBA值上升至35μmol/L以上胎儿宫内窘迫的发生率明显上升。结论TBA值是预测ICP患者胎儿宫内状况敏感指标之一。

Objective To study the relationship between the level of serum total bile acid（TBA） and fetal distress of intrahepatic cholestasis pregnancy（ICP）. Methods 357 patients with ICP were devided into two groups, fetal distress group and non -fetal distress group. Their levels of TBA were collected retrospectively. Results The incidence rates of fetal distress rose with the increasing level of TBA. As the level of TBA was over 35umou/L, the incidence rates of fetal distress rose significantly. Conclusion The study suggest that the level of TBA maybe one of sensitive marker to preditect fetal distress.