摘要
将壳聚糖与环氧丙烷反应,通过控制反应条件制备出取代度为0.56的羟丙基壳聚糖。改性后的羟丙基壳聚糖水溶性增强,将其配制成适当质量浓度的水溶液,利用离子凝胶法,与一定质量浓度的多聚磷酸钠反应,形成了粒径在500~700nm的羟丙基壳聚糖纳米微粒,透射电镜图像显示制备出的纳米微粒形状规整。
Hydroxypropyl-chitosan with substitution degree of 0.56 is prepared by the reaction of chitosan and epoxypropane by controlling condition. The water solubility of modified hydroxypropyl-chitosan is enhanced. When suitable concentration of hydroxypropyl-chitosan water solution responds to certain concentration of sodium polyphosphate based on ion gel method, the hydroxypropyl-chitosan nano-spheres with particle size of 500-700 nm are obtained. Transmission electron micrograph shows that the shape of prepared hydroxypropyl-chitosan nano-sphere is uniform.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第23期4546-4548,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
江西省自然科学基金资助,课题名称:生物法制备低聚壳聚糖的研究(0620071)
航空高校科研基金资助,课题名称:壳聚糖基纳米粒子的制备与表征(EA200502138)~~