幽门螺杆菌基因特征与宿主临床结果相关性研究进展

The relation of Helicobacter pylori genetic characteristic with the host clinical outcome

幽门螺杆菌感染是全世界最常见的慢性感染,其致病机制涉及到菌体毒力因子、宿主及感染后引起的炎症与免疫反应等多方面因素。近年来,随着幽门螺杆菌全基因组测序的完成,幽门螺杆菌基因多态性逐渐成为研究的热点。本文对幽门螺杆菌相关毒力基因cagA、vacA、各黏附基因、oipA、iceA及dupA基因结构多态性、编码蛋白功能的差异及其与宿主临床结果之间的相关性作一综述。

Helieobaeter pylori infection is a common chronic infected disease in all over the world, the pathogenic mechanism of the infection may involve a combination of the bacterial factors, host factors, as well as some environnement factors. Recently, with the realization of the genome sequencing of helicobaeter pylori, genetic polymorphisms become gradually the focal point of the studies on helicobacter pylori. This article aimes to review the various virulent genes of H. pylori, such as cagA, vacA, adhesin genes,oipA,iceA and dupA, their structural polymorphisms, the fuction of the proteins that they encode, and the relation with the host clinical outcome.