贲门癌组织中sPLA2(Ⅱa)的表达

Expression of sPLA2(Ⅱa) protein in gastric cardia adenocarcinoma tissue

目的探讨河南贲门癌高发区贲门癌组织中sPLA2(Ⅱa)的表达。方法采用免疫组化卵白素-生物素-过氧化物酶复合物(ABC)法分析80例贲门癌组织和16例贲门癌旁肠化组织中sPLA2(Ⅱa)的表达情况。结果sPLA2(Ⅱa)在癌旁肠化组织中的表达高于贲门腺癌组织(75.0%vs37.5%,P<0.05),高、中、低分化贲门腺癌sPLA2(Ⅱa)阳性率分别为38.5%、27.6%、48.0%,三组表达率差异无统计学意义(P>0.05)。结论sPLA2(Ⅱa)可能参与了贲门癌的癌变过程。

Objective To characterize the alterations of sPLA2（Ⅱ a） in gastric cardiac adenoeareinoma（GCA） from the high-incidence area for GCA in Henan. Methods sPLA2 （ Ⅱa） expression was detected by immunohistoehemieal method （ABC） in 80 GCA patients and 16 cases with intestinal metaplasia（IM） adjacent to gastric eardia adenoeareinoma （GCA）. Results The positive rate of sPLA2 （ Ⅱ a） in intestinal metaplasia was higher than that in GCA （75.0% vs 37.5% ,P 〈 0.05）. The positive sPLA2 （ Ⅱ a） expression in advanced, moderately differentiated and poorly differentiated GCA were 38.5% , 27.6% , 48.0% , respectively, and the difference was not significant（ P 〉0.05 ）. Conclusion sPLA2（ Ⅱ a） may play an important role in the carcinogenesis of GCA.