动脉内插管灌注化疗治疗鼻型NK/T细胞淋巴瘤

The chemotherapy curative effect of lethal midline granuloma treated with superficial temporal artery injection

目的:本文通过对12例采用颞浅动脉逆行插管灌注化疗治疗的鼻型NK/T细胞淋巴瘤病例进行研究,对化疗疗效、毒副反应情况进行分析。方法:12例患者,男性9例,女性3例;年龄最小22岁,最大65岁。病理确诊为鼻型NK/T细胞淋巴瘤8例;病理诊断为"慢性炎症",临床确诊为鼻型NK/T细胞淋巴瘤4例。10例患者因累及面部中线两侧,故采用双侧颞浅动脉插管颌内动脉灌注化疗。方案采用顺铂(Cisplatin)13-25mg/m2,d1-5,d29-33;足叶乙甙(Etopside)100mg.d-1,d1-5,d29-33;平阳霉素(Pinyangmycin)10mg/d,d1-5,d29-33;甲环亚硝尿(Me-CCNU)100-150mg/d,d1;强的松(Prednisone)25mg/m2,d1-14。所有患者采用颞浅动脉插管灌注完成了一周期化疗。第56天评价疗效。结果:所有患者经动脉灌注化疗一周期后,CR:6例,PR:4例,NC:2例。本组患者毒性反应以血液毒性为主。无因毒性反应影响治疗或因毒性反应退出治疗者。结论:PDD+Vp16+PYM+Me-CCNU+PED动脉内插管灌注化疗治疗鼻型NK/T细胞淋巴瘤具有较好的临床疗效,值得进一步研究。

Objective ：This essay reports chemotherapy curative effect and toxicity of 12 cases who had lethal midline granuloma which treated with superficial temporal artery injection. Methods：12 cases of lethal midline granuloma including 9 cases of males and 3 cases of females with ages from 22 to 65.7 cases had pathologic diagnoses , one had pathologic diagnosis of Wegener＇s granuloma , 4 cases were clinically defined lethal midline granuloma notwithstanding their pathological diagnoses were chronic inflammation. 10 cases were used both sides of superficial temporal artery because tumour involved both sides of maxillas. Chemotherapy regimen： cisplatin 13 -25mg/m^2 ,d1-5 ,d29-33 ; Etopside 100mg/d, d1 -5 ,d29-33 ; Pinyangmycin 10mg/d, d1 -5, d29-33 ; Me - CCNU 100 - 150mg/d, d1. Results： After one cycle of chemotherapy, among all the patients, CR： 6 cases , PR： 4 cases ,NC： 2 cases,No PD cases . The main toxicity is of blood. None gave up chemotherapy for the reason of toxicity. Conclusion： Superficial temporal artery injection chemotherapy by use of PDD ＋ Vp16 ＋ PYM ＋ Me - CCNU ＋ PED can have a high effect in treating lethal midline granuloma.