羟脯氨酸在胸腔积液鉴别诊断中的价值

Diagnostic value of hydroxyproline (HYP) between tuberculous and malignant thoracic pleural effusion

目的:检测胸水中羟脯氨酸(hydroxyproline,HYP)的含量,探讨其对良恶性胸腔积液鉴别诊断的价值。方法:测定96例胸腔积液病人的胸水HYP,判断其性质属恶性胸腔积液或结核性胸腔积液。结果:结核性胸腔积液HYP的含量为(58.11±15.34)μg/ml,恶性胸腔积液HYP的含量为(41.80±11.81)μg/ml,二者相比P<0.01;结核性与恶性胸腔积液的蛋白含量分别为(46.89±8.61)g/L和(37.42±8.39)g/L,P<0.01;包裹与未包裹相比均有显著差异(P<0.01)。HYP对良恶性胸液诊断的灵敏度是84%,特异度是73.68%。结论:胸腔积液HYP的检测对结核性与恶性胸腔积液有鉴别诊断价值。

Objective：To observe the value of （hydroxyproline, HYP） in differential diagnosis of hydrothorax. Methods： We detected HYP in pleural fluid of 96 patients with pleural effusion. Results ： The HYP of tuberculous and malignant exudates was （58.11 ± 15.34） μg/ml and （41.80 ± 11.81 ） μg/ml respectively （P 〈 0.01 ）. The protein of tuberculous and malignant exudates were （46.89 ± 8.61 ） g/L and （37.42 ± 8.39 ） g/L,P 〈 0.01 ;The encysted and unencysted thoracic was different obviously. The HYP level in pleural effusion diagnosis test for malignant sensitivity was 84% and specificity was 73.68%. Conclusion： Examination of HYP has the differential diagnosis value between tuberculous and malignant thoracic plenural effusion.