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SOD、CYFRA21-1及CA125联合检测在卵巢癌诊断中的意义 被引量:2

Combined Detection of SOD,CYFRA21-1 and CA125 in diagnosis of ovarian carcinoma
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摘要 目的:探讨超氧化物歧化酶(SOD)、CYFRA21-1及CA125检测在卵巢癌诊断中的意义。方法:测定83例卵巢癌、35例卵巢良性病变及30例正常妇女血清总超氧化物歧化酶(T-SOD)、锰超氧化物歧化酶(Mn-SOD)、CYFRA21-11及CA125,并作比较分析。结果:卵巢癌患者血清Mn-SOD水平较卵巢良性病变及正常妇女明显降低(P<0.05或0.01),CYFRA21-1及CA125水平明显升高(P<0.05或0.01),Mn-SOD、CYFRA21-1及CA125的敏感性分别为74.7%、81.9%和79.5%。三者联合检测可使敏感性提高到95.1%,准确度提高到94.7%。结论:联合检测Mn-SOD、CYFRA21-1及CA125对卵巢癌诊断有一定的临床应用价值。 Objective:To study the significance of superoxide dismutase(SOD) ,CYFRA21 - 1 ,and cancer antigen 125 (CA125) in diagnosis of ovarian carcinoma. Methods:Serum level of total of SOD manganese superoxide dismutase( Mn -SOD) ,CYFRA21 - 1 and cancer antigen 125( CA125)were measured in 83 patients with ovarian carcinoma ,35 with benign ovarian tumor and 30 normal women as controls. Results:The level of Mn- SOD was significantly lower than that of the benign ovarian tumor and normal women(P 〈 0.05 or 0.01 ) ,the level of CYFRA21 -1 and CA125 was significantly higher than that( P 〈 0.05 or 0.01 ). The sensitivity in diagnosis of ovarian carcinoma were 74.7% ,81.9% and 79.5% for Mn - SOD,CYFRA21 - 1 and CA125. The sensitivity and veracity were 95.1% and 94.7% of combined detection. Conclusion: Combined detection of Mn - SOD, CYFRA21 - 1 and CA125 in diagnosis of ovarian carcinoma is useful.
出处 《现代肿瘤医学》 CAS 2008年第7期1218-1219,共2页 Journal of Modern Oncology
关键词 卵巢癌 超氧化物歧化酶 细胞角蛋白19片段抗原21—1 糖链抗原 ovarian carcinoma superoxide dismutase cytokeratin 19 fragment cancer antigen 125
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二级参考文献4

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