SOD、CYFRA21-1及CA125联合检测在卵巢癌诊断中的意义

Combined Detection of SOD,CYFRA21-1 and CA125 in diagnosis of ovarian carcinoma

目的:探讨超氧化物歧化酶(SOD)、CYFRA21-1及CA125检测在卵巢癌诊断中的意义。方法:测定83例卵巢癌、35例卵巢良性病变及30例正常妇女血清总超氧化物歧化酶(T-SOD)、锰超氧化物歧化酶(Mn-SOD)、CYFRA21-11及CA125,并作比较分析。结果:卵巢癌患者血清Mn-SOD水平较卵巢良性病变及正常妇女明显降低(P<0.05或0.01),CYFRA21-1及CA125水平明显升高(P<0.05或0.01),Mn-SOD、CYFRA21-1及CA125的敏感性分别为74.7%、81.9%和79.5%。三者联合检测可使敏感性提高到95.1%,准确度提高到94.7%。结论:联合检测Mn-SOD、CYFRA21-1及CA125对卵巢癌诊断有一定的临床应用价值。

Objective：To study the significance of superoxide dismutase（SOD） ,CYFRA21 - 1 ,and cancer antigen 125 （CA125） in diagnosis of ovarian carcinoma. Methods：Serum level of total of SOD manganese superoxide dismutase（ Mn -SOD） ,CYFRA21 - 1 and cancer antigen 125（ CA125）were measured in 83 patients with ovarian carcinoma ,35 with benign ovarian tumor and 30 normal women as controls. Results：The level of Mn- SOD was significantly lower than that of the benign ovarian tumor and normal women（P 〈 0.05 or 0.01 ） ,the level of CYFRA21 -1 and CA125 was significantly higher than that（ P 〈 0.05 or 0.01 ）. The sensitivity in diagnosis of ovarian carcinoma were 74.7% ,81.9% and 79.5% for Mn - SOD,CYFRA21 - 1 and CA125. The sensitivity and veracity were 95.1% and 94.7% of combined detection. Conclusion： Combined detection of Mn - SOD, CYFRA21 - 1 and CA125 in diagnosis of ovarian carcinoma is useful.