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CD40和CD40L在大鼠急性心肌缺血中的表达 被引量：1

The expression of CD40 and CD40 Ligand in acute myocardial injury of rats
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摘要 目的探讨黏附分子CD40和CD40配体(CD40 Ligand,CD40L)以及氧化应激在大鼠急性心肌缺血中的表达。方法利用对照组(N组,3只)与急性心肌缺血模型组(A组,6只)作比较,用流式细胞技术法检测外周血中CD40和CD40L表达,比色法检测外周血清中超氧化物歧化酶(SOD)和丙二醛(MDA)的水平。结果急性心肌缺血模型组大鼠外周血中MDA、CD40、CD40L表达均高于对照组(假手术组)大鼠,分别为13.12±2.11和4.69±0.69,16.18±2.48和8.5±3.12,14.91±4.81和6.34±0.2,P<0.01,但SOD则低于对照组大鼠(78.75±10.61和168.90±6.85),P<0.01。结论提示CD40-CD40L的相互作用以及氧化应激可能参与了急性心肌缺血的机制。 Objective The expressions of CD40 and CD40 Ligand （CD40L） in acute myocardial injury of rats. Methods There are 2 animal groups include the control group （n=3）, the acute myocardial injury group （n=6）. The changes of CD40 and CD40L expression of circulating by flow cytometry were determined. The SOD and MDA in serum are detected by spectrophotometer. Results The expressions of CD40 and CD40L as well as MDA are higher in acute myocardial injury group than those in control group, but the expression of SOD is lower in acute myocardial injury group than that in control group. Conclusion The results suggest that the expressions of CD40 and CD40L as well as oxidation stress may contribute to the acute myocardial injury of rats.
作者 吴旻 闫纯英 许端敏 李玉光
机构地区 汕头大学医学院第一附属医院心内科
出处 《中国心血管病研究》 CAS 2008年第7期548-550,共3页 Chinese Journal of Cardiovascular Research
关键词 黏附分子 氧化应激 急性心肌缺血 Adhesion factor Oxidation Stress Acute myocardial injury
分类号 Q95-33 [生物学—动物学] R542.2 [医药卫生—心血管疾病]
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参考文献9

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共引文献8

同被引文献7

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  • 7胡天勇,刘鹏,解金红,关怀敏.不稳定性心绞痛患者基质金属蛋白酶-1与细胞分化抗原40配体的研究[J].中华老年多器官疾病杂志,2008,7(2):117-120. 被引量：2

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中国心血管病研究
2008年 第7期

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