醒脑静治疗蛛网膜下腔出血临床分析

Clinical study of Xingnaojing on subaracnoid hemorrhage

目的探讨醒脑静治疗蛛网膜下腔出血(SAH)的方法和疗效。方法随机将50例SAH患者分为醒脑静组(25例)和对照组组(25例)。对照组应用常规药物包括尼莫地平,醒脑静组在常规药物治疗基础上加用醒脑静治疗。行经颅多普勒(TCD)动态检测大脑中动脉、颈内动脉颅外段的平均血流速度及脉动指数,评定治疗效果。结果醒脑静组的脑血管痉挛(CVS)发病率明显低于对照组(P<0.05),持续时间也明显缩短(P<0.05)。第7d及第10d时醒脑静组平均血流速度(VMCA)较对照组有明显降低(P<0.05),2组间脉动指数(PI)值无明显差异(P>0.05)。结论醒脑静可显著降低SAH患者的大脑中动脉血流速度(MCA),降低CVS发生的频率,缩短CVS持续时间,减弱CVS的强度,认为醒脑静治疗对防治CVS有显著作用。

Objective To study the protective effect of Xingnaojing on subarachnoid hemorrhage. Methods Fifty patients were divided into two groups randomly： control group and Xingnaojing group, based on the routine treatment, Xingnaojing was used for brain protection. TCD evaluation was performed. Results Xingnaojing caused a significant reduction in the incidence rate and maintain time of CVS in Xingnaojing group. In Xingnaojing group, VMCA was significantly lower than control group（P〈0.05）, especially on the seventh and tenth day, but PI had not significantly difference between two groups. Conclusion Xingnaojing can significantly slow the blood flow velocity of MCA, decrease the incidence rate of cerebral vasospasm. It may provide brain protection on CVS.