凯时与赛莱乐联合治疗糖尿病周围神经病变临床观察

Clinical observation on the effect of Alprostadil combined Buflomedil treating diabetic peripheral neuropathy

目的观察凯时与赛莱乐联合治疗糖尿病周围神经病变的临床疗效。方法选择确诊的56例2型糖尿病患者合并皮肤感觉异常,四肢麻木,疼痛及走路不稳或活动受限,肌电图显示神经传导功能障碍;排除其他原因所致周围神经病变的患者。随机分为治疗组30例,对照组26例。均以饮食及胰岛素控制血糖,治疗组凯时10μg,赛莱乐200mg各加入生理盐水250ml静滴,1次/d,2周为1疗程。对照组给予维生素B1100mg,维生素B6100mg,维生素B121000μg,香丹注射液20ml静滴,1次/d,共2周。观察2组治疗前后症状改善情况并用肌电图测正中神经、腓神经的运动传导速度(MCV)及感觉传导速度(SCV)。结果2组用药后自觉症状均有所改善,治疗组明显优于对照组;正中神经、腓神经的运动传导速度及感觉传导速度均有所改善,但治疗后治疗组明显优于对照组,治疗组总有效率93.3%,对照组总有效率69.2%,2组疗效比较差异有显著性(P<0.01)。结论凯时联合赛莱乐治疗糖尿病周围神经病变是一种有效的方法。

Objective To investigate the clinical effectiveness of Alprostadil combined Butlomedil in the treatment of diabetic peripheral neuropathy（DPN）. Methods 56 DPN patients were randomly divided into treatment group and control group. Treatment group received Alprostadil combined Buflomedil; Control group received the treatment of Vit B1, Vit B6, Mecobalamin and Xingdan injection. The changes of symptom and motor nerve conduction velocity （MNCV）, sensory nerve conduction velocity（SNCV） of each group were observed before and after treatment. Results Clinical symptom,MNCV and SNCV in treatment group were better thanthose in control group. Conclusion Alprostadil combined Buflomedil are effective on DPN.