摘要
目的:研究阿托伐他汀的调脂疗效及其对血液中炎症因子的影响。方法:选择于我院门诊诊断的30例高胆固醇血症(HC)的患者(LDL-C>3.64mmol/L)接受8周治疗,于治疗前后、治疗4周末及8周末采空腹静脉血测血脂4项、高敏C-反应蛋白(hs-CRP)。结果:治疗4周末治疗组血清LDL-C、总胆固醇(TC)、hs-CRP水平均明显降低,治疗8周末LDL-C、TC未见进一步下降,但hs-CRP仍有进一步降低。结论:阿托伐他汀降低炎症因子的作用是独立于调脂作用的,且10mg/d的治疗剂量能有效降低高胆固醇血症患者的血清LDL-C与TC水平。
Objective：To observe the influence of treatment with atorvastatin on the inflammatory factors in hypercholesterolemic patients.nethods：Hypercholesterolemic patients （LDL-C〉3.64 mmol/L）received 8-week treatment. The fasting serum lipid was measured at the end of 4-week and 8-week ,and the serum hs-CRP were measured too.Results：Compared with the pretreatment,the level of LDL-C,TC ,hs-CRP remarkably reduced in treatment group at the end of 4-week therapy. These inflammatory parameters did not further reduced,but hs-CRP reduced further at the end of 8-week therapy. Conclusion：Atorvastatin reducing inflammatory factors is independent of lipid-modifying ability, and atorvastatin treatment can effectively reduce the level of LDL-C and TC with 10 mg/d.
出处
《中国医药导报》
CAS
2008年第19期64-65,共2页
China Medical Herald
关键词
阿托伐他汀
高胆固醇血症
高敏C-反应蛋白
Atorvastatin
Hypercholesterotemia
High sensitivity C-reactive protein
