胆管癌患者血清CEA、CA19-9、CA242联合检测的临床意义

Study of relationship between cholangiocarcinoma with CEA,CA19-9 and CA242 in bile and blood

目的:探讨胆管癌患者血清CEA、CA19-9、CA242的检测对其诊断的临床应用价值。方法:采用化学发光免疫法及放射免疫分析法对148例胆管癌患者血清CEA、CA19-9、CA242进行检测。结果:CEA、CA19-9、CA242敏感性分别为52.70%,82.43%,63.51%,联合检测敏感性为89.89%,较单独检测明显提高。CA19-9在术后2周明显下降,对判断胆管癌的预后可能有重要意义。结论:三种标志物联合检测可明显提高胆管癌的检出率,降低漏检率;CA19-9在监测胆管癌术后复发中可能具有较大的临床价值。

Objective：To investigate the clinical value of CEA,CA19-9 and CA242 in the diagnosis of cholangiocarcinoma patients.Metbods：CEA,CA19-9,CA242 in 148 cases were detected in Chemiluminescent immunoassay and radioimmunoassay .Results：The sensitivity rates of using single positive diagnostic indicator of CEA,CA19-9,CA242 to cholangiocarcinoma were 52.70% ,82.43% and 63.51%, respectively, in combined detection for three tumor markers, the sensitivity rates increased to 89.89%, obviously higher than in single delection. CA19-9 decreased sharply two weeks later after operation, it indicated that CA19-9 was an important marker on prognosis of cholangiocarcinoma.Conclusion：In combined detection for the three tumor markers would obviously increase cholangiocarcinoma diagnosis rates and decrease missed diagnosis rates. It might have an important clinical value of CA19-9 on monitoring postoperative recurrent cholangiocarcinoma.