干扰素治疗宫颈上皮内瘤变Ⅰ级的临床疗效分析

Clinical analysis on effective of α - interferon in treatment CIN Ⅰ patients combined with HPV infection

目的探讨α-干扰素治疗宫颈上皮内瘤变Ⅰ级（CINI）合并人乳头瘤病毒（HPV）感染的临床疗效。方法选择2005年5月～2007年5月在我院妇科门诊行宫颈分泌物HPV荧光定量PCR检测阳性，经新柏氏液基细胞学（TCT）和组织病理学检查确诊为CINI合并HPV感染的患者119例，按自愿分成A、B、C三组，A组46例应用α-干扰素行宫颈注射治疗，B组38例应用聚甲酚磺醛栓放置于阴道内治疗，C组35例无任何治疗。治疗三个月后复查，观察CINI合并HPV感染的治愈率。结果A组治愈率84．8％（39／46），B组治愈率39．5％（15／38），C组自愈率22．9％（8／35）。A组治愈率分别与B组、C组比较，有显著性差异（P〈0．01，P〈0．01），B组治愈率与c组比较，无显著性差异（P〉0．05）。结论应用α-干扰素宫颈注射治疗CINI能有效阻断其病变发展，且能清除HPV感染，是一种简便可行、疗效显著的方法，值得临床推广应用。

Objective To evaluate the effective of α- interferon in treatment Cervical Intraepithelial Neoplasia Ⅰ （ CIN Ⅰ ） combined with HPV（human papilloma virus） infection. Methods The objects of this study were the CIN I patients combined with HPV infection to come to out - patient department Gynecology in Baoan people＇s hospital of Shenzhen from May. 2005 to Jun. 2007. CIN Ⅰ was diagnosed by the approaches of Liquid -based mono Lagers（TCT） and colposcopy and pathological examination. All patients tested for HPV were positive. Totally 119 women were accordant with the conditions as research objects, and they were classified as treatment group A （46 cases）, treatment group B（38 cases）and control group C（35 cases） , and the patients in treatment group A had accepted the treatment of α- interferon which was injected into the cervix, the patients in treatment group B had accepted the treatment of policresulen. Results In group A, 39 patients of them were cured finally, the cure rate was 84.8%. In group B, 15 of them were cured finally, the cure rate was 39.5 %. For group C,8 cases recovered to normal automatically, the percentage was 22.9%. Comparing the cure rate between group A and group B, and between group A and group C, the differences were statistically significant （P 〈0.01, P 〈 0. 01 ）. There was no significant difference between group B and group C （P 〉 0. 05）. Conclusion The cervical injection treatment of α- interferon is effective to CIN Ⅰ.