Binswanger型白质脑病危险因素的探讨

A Study on the Risk Factors of Binswanger′s Leukoencephalopathy (BE)

为了探讨Ｂｉｎｓｗａｎｇｅｒ型白质脑病（ＢＥ）的危险因素，对１２２例ＢＥ患者进行了１∶１配队的病例对照研究，资料分析采用条件ｌｏｇｉｓｔｉｃ分析方法。单因素分析发现血管性痴呆家族史、高血压、糖尿病、冠心病、短暂性脑缺血发作、脑出血、脑梗塞、肾功能不全、饮酒、吸烟与ＢＥ发生有关联，未发现体重指数、文化程度、家庭人均收入、性格以及重大不良生活事件与ＢＥ有关联。多因素分析结果表明高血压、短暂性脑缺血发作、冠心病、血管性痴呆家族史。

A matched case control study (1∶1) was carried out among 122 hospitalized patients with Binswanger′s leukoencephalopathy to explore the possible risk factors of BE.Data collected were processed with conditional logistic regression analysis. Individual logistic analysis showed that family history of vascular dementia,history of hypertension,diabetes,coronary heart disease,transient cerebral ischemic attacks(TIAs),cerebral ischemia,cerebral hemorrhage,renal disfunction, alcohol intake smoking were risk factors while healthy life style played protective effect.Body weight index,average family income,education level and type A behavior scores did not show close relations with BE.Multiple regression analysis showed that hypertension,TIAs,coronary heart disease,diabetes and family history of vascular dementia were independent risk factors.