摘要
目的:高效液相色谱法测定酮康唑乳膏中酮康唑的含量。方法:采用Kromasil C18色谱柱,流动相为0.05mol·L^-1醋酸铵溶液-甲醇(26:74)(用稀醋酸调pH至6.5);检测波长239nm。结果:线性范围20mg·L^-1~1.0g·L^-1,r=0.9999,平均加样回率为99.9%,RSD=0.56%。结论:本法操作简便,准确度高,精密度好。
Objective:An HPLC method was established for simultaneous determination of Keteoonazole in Ketoeonazole Cream. Methods:A Kxomasil C18 column was used with 0.05 mol · L^ -1 ammonium acetate-methanol (26: 74) (pH value was adjusted to 6. 5 by diluted acid) as mobile phase. Results: The detecting wavelength was 239 nm. The linear range of Ketoconazole was 20 mg · L ^- 1 - 1.0 g · L ^-1 ( r = 0. 999 9), Conclusion :The average recovery rate and RSD were 99.9% and 0. 56% . The method had good precision. The result was accurate and reliable.
出处
《中国药品标准》
CAS
2008年第3期227-229,共3页
Drug Standards of China