生殖器疱疹病因学分析及其与HIV感染的关系

Research on etiopathogenisis of genital herpes and its relation to HIV infection

目的:了解以生殖器疱疹为主要表现的疾病的病因及与人类免疫缺陷病毒(HIV)感染的关系。方法:采取生殖器溃疡处分泌物进行荧光定量PCR、暗视野显微镜和血清学检查,同时检测单纯疱疹病毒(HSV)、人乳头瘤状病毒(HPV)6/11、梅毒螺旋体(TP)及人类免疫缺陷病毒(HIV)。结果:在226例患者中,检出生殖器疱疹134例、梅毒36例、尖锐湿疣21例,分别占59.29%、15.93%、9.29%,HIV感染2例,占0.88%,其中生殖器疱疹合并梅毒9例,占3.98%;合并尖锐湿疣12例,占5.31%;合并HIV感染1例,占0.44%;梅毒合并尖锐湿疣6例,占2.65%;合并HIV感染1例,占0.44%。结论:生殖器疱疹主要病因是HSV感染,其次是TP和HPV感染,且存在混合性感染,HSV与HIV的关系有待进一步研究。

Objective：To examine the relationship between human immunodeficiency virus （HIV） infection and etiopathogenisis of venereal disease which mainly displays genital herpes. Methods：The secretions of genital anabrosis were collected for herpes simplex virus （HSV）, human papilloma virus （HPV）, TP and HIV testing by fluorescent quantitative PCR, darkfield microscope and serologic method. Results： In 226 Patients, the prevalences of genital herpes, syphilis condyloma and HIV infection were 59. 29% （ 134 Patients）, 15. 93% （36 Patients） , 9.29% （21 Patients） , and 0. 88% ,respectively. Among them, 3. 98% were coinfection of genital herpes and syphilis, 5.31% were coinfection of genital herpes and condyloma acuminatum. Only one patient was genital herpes and HIV coinfection. The prevalence of syphilis and condyloma acuminatum coinfection was 2. 65% （6 Patients）, syphilis and HIV coinfection was only 0. 44% （1 Patients）. Conclusion .. HSV infection appears to be the main cause of genital herpes, then TP and HPV infection, and coinfection also exists in this examination. The association between HSV and HIV infection should be discussed further.