5-羟色胺转运体基因启动子区多态性与海洛因依赖的关联分析

ASSOCIATION OF HEROIN DEPENDENCE WITH POLYMORPHISMS IN THE SEROTONIN TRANSPORTER PROMOTE GENE

目的:探讨云南省汉族海洛因依赖患者5-羟色胺转运体基因启动子区多态性(5-HTTLPR)和海洛因依赖的关联关系。方法:采用病例-对照研究设计,运用聚合酶链式反应检测云南省217例海洛因依赖者和102例正常对照的5-HTTLPR。探讨5-HTTLPR与海洛因依赖是否相关。结果:海洛因依赖和正常对照两组间基因型频率及等位基因频率分布无显著性差异。结论:5-HTTLPR的基因多态性与海洛因依赖无统计学关联,5-HTTLPR可能不是海洛因依赖的易感基因。

Objective ：To explore the relationship between polymorphisms in serotonin transporter promoter gene and heroin dependence among Han heroin dependent patients in Yunnan. Methods：The serotonin transporter gene linkage polymorphism region （5-HTTLPR） was investigated by polymerase chain reaction restriction fragment length polymorphisms techniques in 217 Han heroin dependent patients and 102 healthy controls in Yunnan. Results：No statistical significant difference in 5-HTTLPR was found between heroin dependent patients and the control subjects. Conclusion：Our data suggests that polymorphism of 5-HTTLPR could not be attributable to heroin dependence.