NICU中新生儿重度高胆红素血症的换血治疗

Clinical study of exchange transfusion in the neonates with severe hyperbilirubinemia in NICU

目的探讨新生儿重度高胆红素血症换血治疗的有效性和安全性。方法对61例重度高胆红素血症的患儿行外周动静脉同步换血,换血中监测生命体征和血糖,换血后监测血常规、血生化检查。结果61例患儿经换血治疗后血清总胆红素和间接胆红素下降50%左右,8例患儿出现贫血,24例患儿出现血小板减少,54例患儿出现高血糖症,无一例出现血钙、血钠及血钾异常改变。结论外周动静脉同步换血治疗能快速降低血清胆红素,对机体内环境影响小,副作用少,是新生儿重度高胆红素血症的重要治疗方法。

Objective To investigate the effectiveness and safety of exchange transfusion for the neonates with severe hyperbilirubinemia.Methods 61 severe hyperbilirubinemia neonates accepted exchange transfusion by peripheral vessels,vital sign and blood glucose were monitored during exchange transfusion.Blood routine and blood biochemistry were monitored after exchange transfusion.Results After exchange transfusion,the level of serum bilirubin decreased obviously.8 cases had symptoms of anemia after exchange transfusion.24 cases had thrombocytopenia and 54 cases had hyperglycemia after exchange transfusion.The level of serum calcium,natrium and kalium kept stable.Conclusions Exchange transfusion is an effective treatment for neonates with severe hyperbilirubinemia.