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妇科手术患者低血浆靶浓度异丙酚-瑞芬太尼靶控输注的效应 被引量:2

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摘要 异丙酚、瑞芬太尼靶控输注(TCI)时,临床上推荐的血浆靶浓度分别为3μg·ml^-1、4ng·ml^-1。当异丙酚与瑞芬太尼复合时,不仅在药效学上产生协同作用,而且在药代动力学上还具有相互作用,异丙酚可增大瑞芬太尼的血浆浓度一时间曲线下面积。由此认为对妇科手术患者,异丙酚复合瑞芬太尼TCI采用推荐的血浆靶浓度可能偏高。本研究拟初步观察降低血浆靶浓度时,异丙酚复合瑞芬太尼TCI的麻醉效果,为临床提供参考。
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2008年第5期479-480,共2页 Chinese Journal of Anesthesiology
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