摘要
对合并应用TL与CsA后6只家兔体内CsA的药物动力学进行了研究.结果表明:合用TL对家兔体内CsA的AUC以及T_(1/2)无显著性影响(P>0.05),使CsA的Vc及CLs明显增大,差异有统计学意义(P<0.05).可能是由于TL在体内分布广泛,与组织亲和力强,降低了CsA的血浆蛋白结合率所致.提示临床合理地合用,TL有减少CsA体内蓄积的趋势.
We have studied the pharmacokinetics of cyclosporineA(CsA) in rabbits after concomitant using triptolide(TL) and CsA. The result is that TL has no significant influence to CsA's AUC and T_(1/2) in rabbits (P>0. 05),but can increase CsA's、 Vc and CLs signifi-cantly (P<0. 05). The possible reason is that TL can be widely distributed to the body,it has a strong affinity with the tissue and can decrease CsA's plasma protein binding rate. This means that it tends to decrease the CsA's accumulation in the body by rational concomitant using TL and CsA in clinic.
出处
《中国临床药学杂志》
CAS
1997年第3期115-117,共3页
Chinese Journal of Clinical Pharmacy
关键词
雷公藤甲素
环孢菌素A
药物动力学
雷公藤
triptolide
cyclosporineA
concomitant drug-use
pliarmacokinetic parameters
