摘要
目的：探讨急性氟乙酰胺中毒的临床特征与诊治。方法：分析近2年经法医验证后确诊的46例急性中毒致死者病例。结果：显示口服重度急性中毒者起病急骤，症状以恶心、呕吐、胸骨后或上腹痛、头晕、抽搐、尖叫及心跳骤停为突出表现。尸检证实病变最严重的脏器依次为心、脑、肺、肝、肾等。结论：用硫靛反应（层析法）从生物和非生物检材中，检出有氟乙酰胺的代谢物氟乙酸存在，为确诊急性氟乙酰胺中毒的敏感而可靠的方法。误服后2～3h洗胃效果甚微，乙酰胺为首选的救治药物。
Aim: A new approach to clinical characteristics、diagnosis and treatment of acute fluoroacetamide poisoning was investigated. Methods: Forty-six deaths caused by acute fluoroacetamide poisoning, confirmed by legal medical experts during past 2 years were analysed. Results: The onset of symptoms after poison ingestion was abrapt. It was manifested by nausea and vomiting, substernal or epigastric pain, dizziness, convulsions restlessness and even cardiac arrest. The autopsy revealed lesions in heart, brain, lungs, liver and kidneys in the order of severity, Conclusion: The presence of fluoroace acid, a metabolite from fluoroacetamide in biological and nonbiological materials is a reliable and sensitive method in the diagnosis of acute fluoroacetamide poisoning. Gastric lavage performed 2~3 hours after ingestion does not help much in the recovery of the metabolite. Acetamide is the drug of choice in the treatment.
出处
《急诊医学》
CSCD
1997年第4期200-201,共2页
