急诊多发伤患者血液SOD、LPO的测定及临床意义

MEASUREMENT AND CLINICAL SIGNIFICANCE OF SOD AND LPO VALUE IN THE EMERGENCY MULTIPLE TRAUMA PATIENTS

目的：研究多发伤对血液SOD活性及LPO含量的影响以及与创伤严重度评分的关系。方法：采用邻苯三酚自氧化抑制法和硫代巴比妥酸反应产物比色分析法检测多发伤患者与正常健康成人的血液SOD活性及LPO含量，并对多发伤患者行创伤严重度评分。结果：多发伤组血液SOD平均活性显著降低（P＜0．001），LPO平均含量显著升高（P＜0．001），ISS值愈高，伤死率愈高。结论：多发伤患者创伤后体内氧自由基的产生与清除平衡失调，造成机体的自由基损伤及脂质过氧化损伤，而创伤严重度与患者的伤愈、死亡存在一定的关系。

Aim: To investigate the level of superoxide dismutase (SOD) and lipoperoxide (LPO) in multiple trauma patients. Methods: Both superoxide (P-SOD and E-SOD) and lipoperoxide (P-LPO and E-LPO) were measured, the injury severity score (ISS) was evaluated as well. Results: In the multiple trauma patients, comparing with the control group, activities of SOD decreased significantly (P<0.001), and the content of LPO increased significantly (P<0. 001). The higher the value of ISS, the higher the mortality. Conclusion: The results suggested that the unbalance between the production of oxygen free radical and its clearance be the mechanism responsible for free oxygen radical and lipoperoxidation injuries in multiple trauma patients. There is a definite corelation between ISS and the patient's prognosis.