摘要
以3,4-二氟苯胺为起始原料,通过高温下缩合、环化、亲核取代等制得目标化合物,该合成工艺简单、反应条件比较温和,总收率提高到64%。
A facile preparation of tetrafluorophthalic acid starting from 3,4 -difluorobenzenarnine. The title compounds were synthesized by condensation, cyclization, nucleophilic and substitution. steps were carried out in moderate conditions to afford an overall yield of 64%.
出处
《有机氟工业》
CAS
2008年第2期11-12,共2页
Organo-Fluorine Industry
关键词
环丙沙星
合成
改进
cipofloxacin
synthesis
improved The reactions of all the
