神经胶质瘤中ING4基因蛋白表达的研究

Expression of the ING4 gene protein in human gliomas

目的探讨ING4基因在神经胶质瘤发生、发展中的作用。方法采用免疫组织化学方法对34例神经胶质瘤患者和24例正常对照组ING4基因的蛋白表达进行研究。结果ING4基因在神经胶质瘤患者中的表达明显低于正常对照组(P<0.001)。ING4基因的表达水平与神经胶质瘤的恶性程度呈负相关(rs=-0.470,P<0.01)。结论ING4基因在神经胶质瘤的发生、发展中可能起重要的作用。

Objective To study the ING4 gene expression in human gliomas and normal brain tissue in order to investigate the role of ING4 gene in the pathogenesis and development of gliomas. Methods 34 specimens of gliomas and 24 specimens of controls （ normal brain tissue） were studied . The expression of INCA gene in gliomas and controls was detected by immunohistochemical method. Results The expression of ING4 gene was significantly reduced in gliomas as compared with normal brain tissue（P 〈0.001 ）. There was a negative correlation between the expression level of ING4 and malignancy grade of gliomas（ r1 = -0.470, P 〈0.01 ）. Conclusion The finding suggests that the ING4 gene plays an important role in the pathogenesis and development of gliomas.