阿魏酸钠治疗短暂性脑缺血发作的疗效观察

Observation of Clinical Effect of Ferulate in the Treatment of Transient Ischemic Attack

目的:观察阿魏酸钠治疗短暂性脑缺血(TIA)发作的疗效及血流变学的变化。方法:将符合标准的入选病例101例分为治疗组和对照组。治疗组52例,给予阿魏酸钠0.2 g,加入250 mL 0.9%氯化钠注射液中静脉滴注;对照组49例,给予丹香冠心注射液20 mL,加入250 mL 0.9%氯化钠注射液中静脉滴注,两组疗程均为14 d,并于治疗结束后随访60 d。结果:2组临床疗效比较,有显著性差异(P<0.05);治疗组较对照组的基本治愈率明显提高(75%vs 50%,P<0.05)。结论:阿魏酸钠治疗TIA疗效确切,可降低脑梗塞的发生率。

OBJECTIVE ： To study the clinical effect of ferulate and the hemorheological change in patients with transient ischemic attack （TIA）. METHODS： A total of 101 patients coincided with the selecting standard were divided into trial group （n = 52） to be treated with ferulate 0.2g in 0.9 % sodium chloride by iv gtt and control group （n = 49 ） with Danxiangguanxin injection 20ml in 0.9 % sodium chloride by iv gtt. The patients in both groups were followed for 60 days after completion of 14 - day treatment. RESULTS： There was significant difference between the two groups in clinical effects （P 〈 0.05）, with the total cure rate in trial group significantly higher than in control group （75% vs. 50%, P 〈 0.05）. CONCLUSION： Treatment of TLA with ferulate has proved efficacy and reduced incidence of cerebral infarction.