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影响5-FU代谢及其耐药机制的研究进展 被引量：1

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摘要 介绍了经典抗肿瘤药物5-FU体内代谢途径,临床上不同5-FU使用方法产生的各种耐药性表现,后者发生机制、影响因素和预测指标等。
作者 王华 侯明星 董培德 叶盛伟 季加孚
机构地区 内蒙古医学院附属医院普通外科 北京大学临床肿瘤学院外科
出处 《中国现代医生》 2008年第17期38-39,共2页 China Modern Doctor
关键词 抗肿瘤药物 5-FU 耐药性 机制 预测
分类号 R979.1 [医药卫生—药品]
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参考文献10

  • 1[1]Mackey JR,lennings LL,Clarke ML,et al.lmmunohistochemical variation of human equilibrative nueleoside transporter 1 protein in primary breast cancers[J].Clin Cancer Res,2002,8 (1):110-116.
  • 2[2]Kikuyama S,lnada T,Shimizu K,et al.p53,bcl-2 and thymidine phosphorylase as predictive markers of chemotherapy in patients with advanced and recurrent gastric eance[J].Antieancer Res,2001,21(3C):2149-2153.
  • 3[3]Hata K,Fujiwaki R,Maede Y,et al.Expression of thymidine phosphorylase in epithelial ovarian cancer:correlation with angiognnesis,apoptosis,and ultrasound-derived peak systolic velocity[J].Gynecol Oncol,2000,77(1):26-34.
  • 4[4]Konno S,Takebayashi Y,Aiha M,et al.Clinicopathalogical and prognostic significance of thymidine phosphorylase and proliferating cell nuclear antigen in gastric carcinoma[J].Cancer Lett,2001,166(1):103-111.
  • 5[5]Sobrero AF,Aschele C,Bertino JR.Fluorouraeil in eolorectal cancer-a tale of two drugs:implications for biochemical modulation[J].J Clin Oncol,1997,15(1):368-381.
  • 6[6]Salonga D,Danenberg KD,Johnson M,et al.Colorcetal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogonase,thymidylate synthase,and thymidine phosphorylase[J].Clin Cancer Res,2000,6(4):1322-1327.
  • 7[7]Uehida K,Hayashi K,Kuramochi H,et al.Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)InRNA expression in colorectal and gastric cancer during continuous tegafur infusion[J].Int J Oncol,2001,19(2):341-346.
  • 8[8]Peters GJ,Backus HH,Freemantle S,et al.Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism[J].Biochim Biophys Acta,2002,1587(2-3):194-205.
  • 9[9]Higashiyama M,Kedama K,Yokouchi H,et al.Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues:relationship with in vitro sensitivity to 5-fluorouracil[J].Lung Cancer,2001,34(3):407-416.
  • 10[10]Pugacheva EN,Ivanov AV,Kravchenko JE,et al.Novel gain of function activity of p53 mutants:activation of the dUTPase gene expression leading to resistance to 5-fluoronracil[J].Oncogene,2002,21 (30):4595-4600.

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中国现代医生
2008年 第17期

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