间歇性短期胰岛素泵强化治疗早期糖尿病肾病

Intermittent Short-term Insulin Pump in Treatment of Early Diabetic Nephropathy

目的观察间歇性短期胰岛素泵强化治疗早期糖尿病肾病的临床疗效。方法将50例2型糖尿病合并早期糖尿病肾病患者,随机分为间歇性短期胰岛泵强化治疗组(25例)及常规治疗对照组(25例)。观察FPG、2hPG、HbA1C、UAER、Uβ2-MGER、胰岛B细胞功能的改变。结果间歇性短期胰岛素泵强化治疗组的观察指标均有明显的改善。结论间歇性短期胰岛素强化治疗不仅能使2型糖尿病病人的血糖维持在良好水平,还能降低早期DN的UAER,防止和延缓糖尿病肾病的发展。

Objective To observe clinical efficacy of intermittent short-term insulin pump in treatment of early diabetic nephropathy. Methods 50 patients with type 2 diabetes with early diabetic nephropathy patients were randomly divided into insulin pump intermittent short-term intensive therapy group（25 cases） and routine treatment control group（25 cases）. Observation of FPG, 2hPG, HbAlC, UAER, U β2-MGER, pancreatic B-cell function changes. Results Intermittent short-term insulin pump intensive therapy group observed indicators have improved significantly. Conclusion Intermittent short-term intensive insulin treatment can not only type 2 diabetes patients maintain good blood glucose levels, but also reduced the early DN UAER, prevent and delay the development of diabetic nephropathy.