卡前列甲酯用于无痛人工流产术前扩张宫颈给药时间的观察

The Observation of Use of PG05 for Cervical Dilation at Different Time before the Painless Artificial Abortion

目的探讨无痛人工流产术前阴道放置卡前列甲酯扩张软化宫颈适宜的给药时间。方法采用前瞻性对比研究,将200例自愿要求行无痛人工流产术的妇女随机分为A、B、C三组,A组卡前列甲酯0.5mg术前1h放入阴道后穹窿,B组术前2h放入阴道后穹窿,C组不采用任何药物行人工流产术。观察并比较各组在人工流产术中宫颈松弛程度、手术时间、术中出血量、手术效果、副反应等参数。结果A组、B组较C组在宫颈松弛程度方面具有极显著性差异(P<0.01)。A组与B组比较无显著性差异(P>0.05)。手术中出血量A、B、C三组比较无显著性差异(P>0.05)。手术时间和手术效果方面A组、B组与C组比较有显著性差异(P<0.05)。结论无痛人工流产术前阴道放置卡前列甲酯0.5mg可以有效地扩张软化宫颈、缩短手术时间、减少受术者痛苦;术前阴道上药时间1h和2h同样有效。

Objective To investigate the optimal administration time of PG05 placed in vagina for cervical dilation before the painless artificial abortion. Methods The prospective comparative study consisted of 200 pregnant women who voluntarily applied for the painless artificial abortion. They were randomly divided into two groups, 100 cases in each group, namely Group A and Group B. Comparison was carried out among those two control groups and Group C who would not use any medicine for artificial abortion. Group A placed 0.5mg PG05 in posterior fornix of vagina 1 hour before operation. Group B placed 0.5mg PG05 in posterior fornix of vagina 2 hours before operation. Cervical relaxation, operation time and blood loss during operation, operation effect and side effect were observed and compared among those groups. Results There was no significant difference in cervical relaxation between Group A and Group B （P〉0.05） while significantly different from Group C （P〈0.01）. There was no significant difference in blood loss among those 3 groups （P〉0.05）. There was no significant difference in operation time and operation effect between Group A and Group B while significantly different from Group C （P〈0.05）. Conclusion Use of 0.5mg PG05 in vagina before painless artificial abortion is significantly helpful in cervical priming, operation time reduction and pain easiness. Either application of PG05 in vagina 1 hour or 2 hours before operation is significantly effective.