老年原发性非小细胞肺癌三维适形放射治疗的临床应用

Three-Dimmentional Conformal Radiotherapy for Non-Small Cell Lung Cancer in the Elderly

目的观察三维适形放射治疗在老年原发性非小细胞肺癌中的治疗效果。方法对50例老年原发性非小细胞肺癌进行适形放射治疗,照射剂量为4000～6000cGy,分次剂量400～500cGy。结果所有患者均完成适形放射治疗,完全缓解(CR)率为48.0%(24/50),部分缓解(PR)率为38.0%(19/50),总有效率(CR+PR)为86.1%(43/50);1、2、3年生存率分别是82.0%(41/52)、52.0%(26/50)和26.0%(13/50);急性放射性肺炎发生率为4.0%(2/50),肺纤维化发生率为20.0%(10/50),经对症支持治疗后均缓解。结论适形放射治疗是一种提高老年原发性非小细胞肺癌患者生存率和生存质量的有效治疗手段。

Objective To discuss the effect of three-dimmentional conformal radiotherapy on non-small cell lung cancer in the elderly. Methods 50 cases over 70-year-old patients with non-small cell lung cancer received three-dimmentional conformal radiotherapy at a dose of 4000cGy to 6000cGy. Results All the cases received three-dimmentional conformal radiotherapy successfully, complete remission（CR） rate was 48.0%（24/50）, partial remission（PR） rate was 38.0%（19/50） and the total efficiency （CR ＋ PR）for the 86.1%（43/50）; 1-,2-and 3-year survival rate were 82.0%（41/52）, 52.0%（26/50） and 26.0%（13/50）; The incidences of acute radiation pneumonitis and pulmonary fibrosis were 20.0%（10/50）, which were cured by medication. Conclusion Three- dimmentional conformal radiotherapy for aged patients with lung cancer is a good therapeutic selection with improved survival quality and identical survival rate.