复发性外阴阴道念珠菌病患者阴道局部免疫状态的变化

The change of local immune condition of vagina in recurrent vulvovaginal candidiasis patients

目的:探讨阴道局部免疫状态与复发性外阴阴道念珠菌病(RVVC)发病的关系。方法:用ELISA法测定外阴阴道念珠菌病(VVC)和RVVC的妇女阴道灌洗液中IgE的浓度及IFN-γ、IL-4的表达水平,以健康体检妇女为对照组。结果:①IgE浓度测定:RVVC组IgE浓度明显高于VVC组和对照组(P<0.05),VVC组高于对照组(P<0.05)。②细胞因子测定:VVC和复发VVC的妇女阴道灌洗液中IL-4和IFN-γ的表达水平均显著高于健康对照组,RVVC组较VVC组的IL-4的表达水平有显著性差异(P<0.05);而IFN-γ的表达水平无显著性差异(P>0.05)。结论:阴道局部免疫状态异常可能与念珠菌性阴道炎发病和复发有关。

Objective：To investigate the relationship between the local immune condition of vagina and the pathogenesis of recurrent vulvovaginal candidiasis.Mcthods：Objectives were divided into 2 gronps：vulvovaginal candidiasis group （VVC） and recurrent vulvovaginal candidiasis group（RVVC）.The lavage of the vagina,concentration of IgE and expression level of the IL-4 and IFN-γ were all measured by ELISA, and compared with normal controls.Results ①Concentration of IgE： the IgE concentration of RVVC group was higher than that of VVC and normal control group. There was significant difference among three groups （P〈0.05）.②Level of Cytokine：The level of IL-4 and IFN-γ in VVC and RVVC group was significantly and respectively higher than that in normal controls （both P〈0.05）; the level of IL-4 in RVVC group was higher than that in VVC group,while no significant difference in the level of IFN-γ between RVVC and VVC group was found （P〉0.05）.Conclusion： The abnormality of local immune condition of vagina might participate in the pathogenesis and the recrudescence of vulvovaginal candidiasis.