摘要
目的观察丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎的临床疗效。方法将55例过敏性紫癜性肾炎患儿随机分为两组。治疗组30例,给予丹芍颗粒号和雷公藤治疗;对照组25例,给予强的松和雷公藤治疗,疗程均为2个月,观察两组患儿治疗前后24小时尿蛋白、尿红细胞、尿N-乙酰-β-D-氨基葡萄糖酐酶(NAG)及T淋巴细胞亚群的变化。结果治疗组完全缓解率46.7%,对照组完全缓解率28.0%,差异有统计学意义(P<0.05)。治疗组在降低血尿、蛋白尿和尿NAG酶方面优于对照组(均P<0.05)。两组治疗前后CD3+和CD8+差异无统计学意义(P>0.05),而两组治疗后CD19+显著降低,CD4+、CD16/56+显著升高(均P<0.05),治疗组优于对照组(P<0.05)。结论丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎有较好临床疗效。
Objective To observe the effect of Danshao Granule Ⅱ on children Henoch-Schonlein purpura nephritis(HSPN).Methods The 55 children with HSPN were divided into treatment group(30 cases) treated with Danshao Granule Ⅱ and Wilfordii Multiglycoside Tablet,and control group(25 cases) treated with prednisone and Wilfordii Multiglycoside Tablet.The changes of both groups in urinary protein,red blood cell,N-acetyl-β-glucosaminidase(NAG) and T cell subsets were observed after 2-month treatment.Results The complete remission(CR) rate of the treatment group was 46.7%,while that of the control group was 28.0%,the difference was significant(P〈0.05).After 2-month treatment,the treatment group was more remarkably improved than the control group(both P〈0.05) in urinary protein,RBC and NAG.CD19^+ of both groups was remarkably decreased,while CD4^+ and CD16/56^+ remarkably increased(both P〈0.05),the treatment group being better than the control group(P〈0.05).Conclusion Danshao Granule Ⅱ has a good therapeutic effect on HSPN children.
出处
《中医杂志》
CSCD
北大核心
2008年第6期517-519,共3页
Journal of Traditional Chinese Medicine
基金
江苏省中医药管理局基金资助项目(H05039)
关键词
过敏性紫癜性肾炎
儿童
丹芍颗粒Ⅱ号
凉血化瘀通络法
Henoch-Schonlein purpura nephritis
Children
Danshao Granule Ⅱ
Cooling blood,dissolving stasis and dredging collaterals