溃疡汤联合西药三联疗法治疗幽门螺杆菌相关性十二指肠溃疡70例临床观察

Clinical Observation on the Effect of Kuiyang Decoction plus Triad-therapy of Western Medicine on 70 Cases of Helicobacter Pylori Related Duodenal Ulcer

目的探讨溃疡汤与西药三联疗法相结合治疗幽门螺杆菌(Hp)相关性十二指肠溃疡患者疗效及其对Hp的根除作用。方法将140例患者随机分为对照组70例,采用西药三联疗法,口服奥美拉唑、羟氨苄青霉素、甲硝唑,均每日2次,连服1周,然后单服奥美拉唑,连服3周;治疗组70例,口服溃疡汤4周,同时口服上述西药,服法同对照组。两组分别于治疗前后检测Hp,并对临床疗效作对比分析。结果胃镜下疗效、Hp清除率、症状改善及治疗后1年复发率,治疗组均优于对照组(P<0.05)。结论溃疡汤合西药三联疗法治疗Hp阳性十二指肠溃疡能够提高Hp根除率,具有较好的疗效。

Objective To study the effect and eradication of Kuiyang Decoction（decoction for ulcer） plus triad-therapy of western medicine on helicobacter pylori（Hp） positive duodenal ulcer.Methods The 140 cases were randomly divided into two groups.The control group,70 cases,was treated by standard triad-therapy：omeprazole,amoxicillin and metronidazole per os for one week in succession,then only omeprazole,20mg each time,twice a day,3 weeks in succession.The treatment group,70 cases,was treated by Kuiyang Decoction per os,one dose each day,for 4 weeks in succession in addition to taking the above-mentioned western medicines in the same way as the control group.Before and after treatment both groups were given the Hp test for comparing the therapeutic effect.Results The treatment group was better than the control group in the effect under gastroscope,Hp eradication rate,symptom improvement,and one-year recurrent rate（P〈0.05）.Conclusion The combination of Kuiyang Decoction plus triad-therapy of western medicine for the treatment of Hp positive duodenal ulcer is remarkable in improving eradicative rate of Hp.