含手性双环胍的氨基酸受体的合成

Synthesis of an Receptor Containing Chiral Bicyclic Guanidine for Amino Acids

报道含有手性双环胍、氮杂冠醚及萘甲酰基3个分子识别点的芳香族氨基酸人工受体的合成．

An artificial receptor 1 for aromatic amino acids was prepared from a chiralbicycllc guanidine salt 2 by means of a new procedures. The deprotecting silylethers 2 and 4were selectively achieved in solutions of CH3COOH-THF-H2O and HF-Pyridine respectively.Thus the receptor 1 was readily obtained upon reaction of the monosubstituted naphthoylester 5 with bromoacetic acid and then mono-azacrown ether. The total yield in five steps was40.5%.