(±)-Salvinolone的全合成研究

Studies on the First Total Synthesis of (±)-Salvinolone

以2－（3，4-环己基烯二氧-5-异丙基）苯基乙醇（2）和3-异丙氧基-5，5-二甲基-1，3-环己烯酮（4）为原料，利用羰基α-位的烷基化反应和分子内的Friedel－Crafts反应为关键步骤，经9步反应，合成了多氧芳香型三环二萜类天然产物Salvinolone．

Salvinolone is a polyoxygenated aromatic tricyclic diterpene which was firstisolated from the roots of Salva prionitis. The assignment of its structure for compound 1 wasmostly made on the basis of spectral data. In order to confirm the assigned structure, aconvergent synthesis of Salvinolone(1) has been achieved in nine steps, starting with3-fisopropoxy-5, 5-dimethyl-2-cyclohexenone (4) and alcohol (2) which are readily available. Thekey steps are alkylation of carbonyl compound and intramolecular Friedel-Crafts reaction.This is the first total synthesis of (±)-salvinolone.