海鞘中抗肿瘤活性物质的研究概况

The Recent Progress of Antitumor Substances from Ascidians

海鞘的生理活性物质是海洋天然产物化学中引人注目的研究领域之一。近年来,从海鞘中分离出许多结构新颖、生理活性显著的新化合物,引起了有机化学家和药物学家等的日益重视。本文按肽、稠环芳香族生物碱、脂肪族生物碱、多硫化物、大环内酯、萜类化合物等化学结构分类综述海鞘抗肿瘤成分的研究进展。

The chemistry of ascidians has become one of the most active fields of marine natural products. A great deal of compounds with unusaual structures and significant bioactivities have been isolated from various ascidians. This review describes the recent progress in the antitumor substances of ascidians according to structural classifications such as peptides, polycyclic aromatic alkaloids, aliphatic alkaloids, polysulfides, macrolides and terpenoids.