复苏饮对心脏骤停复苏犬脑细胞超微结构影响的实验研究

The Empreriencal Study on Protective Effect of FuSuyin on Brain Cell Ultramicrostructure in Post Resuscitation Dog from Cardiac Arrest

目的:观察复苏饮对犬心脏停跳复苏后脑组织超微结构的影响。方法:将健康犬随机分为假手术组、模型组和复苏饮组,后两组复制心脏骤停和复苏模型;观察各组循环建立时肾上腺素、阿托品用量及循环恢复时间;在电镜下观察复苏犬自主循环恢复180min后大脑皮层脑组织超微结构。结果:与模型组相比,复苏饮组复苏所用肾上腺素、阿托品用量明显减少,总复苏时间明显缩短,脑组织病理损害亦明显减轻。结论:复苏饮能明显减少肾上腺素用量,减轻脑组织形态学损害,对复苏犬脑细胞有保护作用。

Objective ： To investigate the protective effect of FuSuyin on brain cell ultramicrostructure in post resuscitation dog from cardiac arrest. Methods： adult healthy dogs were randomly allocated into 3 groups：sham group; model group and FuSuyin treatment group. Cardiac arrest was induced of the last two groups. To observe the dosage of the adrenalin and Atropine and circulation recovery time when circulation established on each group. To observe the cerebral cortex uhramicrostructure under electron microscope when independent circulation recovered 180 minutes. Results： Compared with sham group, the dosage of the adrenalin and Atropine and circulation recovery time in FuSuyin treatment group were lower, and the pathological lesion of brain tissue were lessen. Conclusion：The study confirmed FuSuyin can decrease the dosage of adrenalin and Atropine, lessen histomorphology of brain tissue, has protective effect on brain tissue.