女童中枢性性早熟的MR表现

MRI study of pituitary in girls with central precocious puberty

目的通过MRI探讨中枢性性早熟(CPP)女童的垂体腺大小、形态和信号强度变化规律。方法选取40例临床诊断为CPP并有完整MRI资料3～10岁年龄段的女童40例,观察测量矢状面T1加权图像上垂体腺大小、形态及信号特征。结果3～<5岁组腺垂体高度为6.1±0.2mm,5～<10岁组腺垂体高度为6.4±0.4mm;3～<10岁组垂体上缘隆凸型占85.0%(34/40);垂体柄宽径为1.93±0.50mm;垂体后叶均为高信号(100%)。结论CPP女童垂体大小形态变化大,垂体腺明显大于同龄正常儿童,垂体腺明显增生肥大,垂体上缘上凸比率也明显高于同龄正常儿童,垂体腺在MRI上的这种改变反映下丘脑-垂体-性腺轴(HPGA)有过早活动,这种改变对临床诊断CPP有重要的价值及意义。

Objective To study the shape, size and signal intensity of pituitary gland in girls aged 3-10 year old with central precocious puberty. Methods MRI data of pituitary glands in 40 girls aged 3-10 years old with central precocious puberty were selected. The shape, height and the appearances of pituitary glands were measured and observed on sagittal T1WI. Results Quantitative data about size, shape and single intensity changes of pituitary glands in central precocious puberty were obtained in two groups, including girls aged from 3-5 and 5-10. The convex pituitary gland were 85.0%in former group. The height of pituitary gland were 6.1±0.2mm （former group） and 6.4±0.4mm （latter one） respectively. The width of pituitary stalk was 1.93 ± 0.50mm. The posterior pituitary gland demonstrated high signal intensity in all cases. Conclusion Obvious changes of the size and shape of pituitary glands were found in central precocious puberty of girls aged from 3-10. The pituitary glands manifested physiologic hypertrophy with more convex in central precocious puberty girls than in normal ones. The changes on MRI could reflect the function of hypothalamus- pituitary-gonadal axis. It is of important value and significance in the diagnosis of central precocious puberty.