结肠净化对肝性脑病干预的临床研究

A clinical observation on therapeutic effect of colon purification on hepatic encephalopathy

目的 观察结肠净化治疗肝性脑病的临床疗效。方法 将我院收治的肝硬化合并肝性脑病患者117例随机分为两组，治疗组59例，对照组58例，在积极去除诱因基础上，两组患者均给予常规的抗肝性脑病治疗，治疗组在上述治疗的基础上加用结肠净化治疗。比较两组患者治疗前后症状、体征、肝功能、血氨及治疗后恢复清醒时间的变化，总有效率及死亡率，观察治疗前后的肝性脑病分期计分情况。结果 治疗组与对照组比较，治疗组可明显改善患者的症状体征，缩短患者的清醒时间，降低患者的血清转氨酶、胆红素及血氨水平，提高总有效率，降低死亡率，改善肝性脑病的计分值。结论 结肠净化是较为有效的治疗肝硬化合并肝性脑病的疗法。

Objective To observe therapeutic effect of colon purification on hepatic encephalopathy. Methods 117 patients with hepatic encephalopathy treated in our hospital were randomly divided into the treatment group （59 cases） and the control group （58 cases）. Routine anti-coma hepaticum treatments were carried out in both treatment and control groups, and colon purification treatment was performed in the treatment group on basis of routine anti-coma hepaticum. The changes in symptoms and signs were observed, the grading scores of hepatic encephalopathy were evaluated, liver function was tested and blood ammonia level was determined before and after treatment in the two groups. Time for regaining consciousness was recorded after treatment in the two groups. Results The symptoms and signs were obviously improved, time for regaining consciousness was shortened, the grading scores decreased, and serum aminotransferase activity and bilirubin level and blood ammonia level significantly decreased in the treatment group as compared with those of the control group. Total effective rate in the treatment was significantly higher than that in the control group and death rate in the treatment group was significantly lower than that in the control group. Conclusion Colon purification treatment is effective for hepatic encephalopathy due to cirrhosis.