雌、孕激素受体、环氧合酶-2及整合素-β_3在输卵管中的表达及与输卵管妊娠的关系

Expression of ER, PR, COX-2 and Integrin-β_3 in Fallopian Tube and Its Relationship with Fallopian Pregnancy

目的:探讨雌、孕激素受体(ER、PR)、环氧合酶(COX)-2及整合素-β3在输卵管妊娠中的作用。方法:采用免疫组化方法检测35例人妊娠输卵管、17例增生期正常输卵管、17例分泌期正常输卵管黏膜上皮中ER、PR、COX-2及整合素-β3的表达情况。结果:①ER、PR在增生期输卵管中有表达,在分泌期输卵管中表达率较增生期强(P<0.05)。ER、PR在妊娠输卵管中的阳性(+++)表达率比正常输卵管明显降低(P<0.05)。②COX-2在增生期和分泌期输卵管中的阳性(+++)表达率较低,在妊娠输卵管中的阳性(+++)表达率较正常输卵管明显增高(P<0.05)。③整合素-β3在妊娠输卵管中的阳性(+++)表达率与正常分泌期的输卵管无明显差异(P>0.05)。结论:①ER、PR在输卵管黏膜上皮中的表达降低和COX-2表达增强可能与输卵管妊娠相关;②整合素-β3可能不参与输卵管妊娠的发生。

Objective： To understand the function of ER, PR, COX-2 and integrin-β3 in the tube pregnancy. Methods： The expressions of ER, PR, COX-2 and integrin-β3 in the pregnant tube （35 cases）, the normal tube in proliferative （17 cases） and secretory phase （17 cases） were examined by immunohistochemistry. Results： 1） The expression rates ofER, PR in the proliferative and secretory tube were higher, and in the pregnant tube were lower （P〈0.05）. 2） COX-2 expression in pregnant tube was higher than that in the normal tube （P〈0.05）. 3） The expression of integrin-β3 was higher in the pregnant and the secretory tube, and there was no difference in expression level between them （P〉0.05）. Conclusions： 1） The lower expression ofER, PR and higher expression of COX-2 in tube might have a association with the tube pregnancy. 2） Maybe integfin-β3 don＇t take part in the tube pregnancy.