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全反式维甲酸对各种人甲状腺肿瘤细胞株增殖、摄碘及甲状腺特异基因表达的影响 被引量：1

Effects of all-trans retinoic acid on proliferation,iodide uptake and thyroid specific gene expression in different cell lines of human thyroid carcinoma
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摘要 对4种甲状腺癌细胞株予全反式维甲酸处理,四甲基偶氮唑盐法检测细胞增殖,同位素法测定摄碘功能,半定量RT-PCR检测甲状腺特异基因及维甲酸受体表达。结果显示全反式维甲酸可抑制FTC-133细胞增殖,促进其摄碘及甲状腺特异基因的表达,但对C643、HTH74及XTC.UC1细胞无影响,提示不同甲状腺肿瘤细胞对全反式维甲酸的反应性不相同。 Different human thyroid carcinoma cell lines were treated with all-trans retinoic acid （RA）. RA could inhibit cell growth, improve iodide uptake and increase some thyroid specific genes and retinoid acid receptor （RAR） mRNA expressions in FTC-133 cells. However, RA had no effect in C643, HTH74 and XTC- UC1 cells. These findings indicate that different thyroid carcinoma cells display diverse responses to RA.
作者 崔岱 兰玲 刘超 蒋琳 唐伟
机构地区 南京医科大学第一附属医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第6期510-511,共2页 Chinese Journal of Endocrinology and Metabolism
基金 江苏省政府医学重点学科项目基金[苏卫科教(2001)34]
关键词 甲状腺肿瘤 维甲酸 增殖 摄碘 受体 维甲酸 Thyroid neoplasms Tretinoin Proliferation Iodide uptake Receptor, retinoid acid
分类号 R736.1 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献16

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共引文献6

同被引文献21

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中华内分泌代谢杂志
2007年 第6期

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