摘要
成年雄性昆明种小鼠分为对照组、丙基硫氧嘧啶(PTU)组、PTU+T_4组,造模8周后,免疫组化和Western印迹法检测神经颗粒素(Ng)表达,发现甲状腺功能减退(甲减)小鼠海马区Ng表达降低,用T_4治疗可使之恢复,提示海马内Ng减少可能是成年期甲减雄性小鼠认知功能受损的机制之一。
Adult male Kunming mice were divided into normal control group, propylthiouracil (PTU) treated group and PTU + T4 treated group. Neurogranin (Ng) protein expression in the hippocampus after 8 weeks was assayed by Western blotting and immunohistochemical method. Results showed that Ng protein was decreased in the hippocampus of male mice with adult-onset hypothyroidism, suggesting that decreased Ng, which is correctable by T4, is involved in cognitive dysfunction in adult-onset hypothyroid male mice.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2007年第6期519-520,共2页
Chinese Journal of Endocrinology and Metabolism
基金
安徽省自然科学基金(03043708)