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对伴微量白蛋白尿2型糖尿病患者动脉粥样硬化的早期干预 被引量:4

Early intervention of atherosclerosis in type 2 diabetic patients with microalbuminuria
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摘要 160例2型糖尿病患者分为微量白蛋白尿组(MAU组)42例和正常白蛋白尿组(NAU组) 118例。多元逐步回归提示微量白蛋白尿与臂踝脉搏波传播速度(baPWV)和颈动脉内中膜厚度(IMT)独立相关(均P<0.01)。西洛他唑干预后,MAU组baPWV显著下降(P<0.01)。 A total of 160 type 2 diabetic patients were divided into microalbuminuria (42 cases) and normoalbuminuria (118 cases) groups. Multivariate analysis demonstrated that the presence of microalbuminuria was independently associated with brachial-ankle pulse wave velocity (baPWV) and intima-media thickness (both P 〈0.01 ). BaPWV of type 2 diabetics with microalbuminuria was decreased after administration of cilostazol (P 〈 0.01).
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第6期537-538,共2页 Chinese Journal of Endocrinology and Metabolism
基金 福建省自然科学基金计划(C0410041)
关键词 微量白蛋白尿 脉搏波传播速度 颈动脉内中膜厚度 糖尿病 2型 西洛他唑 Microalbuminuria Pulse wave velocity Intima-media thickness Diabetes mellitus, type 2 Cilostazol
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参考文献4

  • 1Hillege HL, Fidler V, Diercks GF, et al. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation, 2002,106:1777-1782.
  • 2Feldt-Rasmussen B. Microalbuminuria, endothelial dysfunction and cardiovascular risk. Diabetes Metab, 2000,26 ( Suppl 4 ) :64-66.
  • 3Wofford JL, Kahl FR, Howard GR, et al. Relation of extent of extracnmial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioseler Thromb, 1991,11:1786-1794.
  • 4Yokoyama H, Aoki T, Imahori M, et al. Subclinical atherosclerosis is increased in type 2 diabetic patients with microalbuminuria evaluated by intima-media thickness and pulse wave vdocity. Kidney Int, 2004,66: 448-454.

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