铜绿假单胞菌分布情况及耐药性分析

Distribution and drug resistance analysis of pseudomonas aeruginosa Isolates

目的分析我院5年来铜绿假单胞菌耐药性的变化，为临床合理使用抗菌药物提供依据。方法用回顾性调查的方法对921株铜绿假单胞菌的标本来源及耐药情况进行分析。结果921株中有57．9％（533／921）来自痰及咽拭子，15．2％（140／921）来自伤口分泌物。药敏结果显示，铜绿假单胞菌对亚胺培南、哌拉西林／他唑巴坦、头孢哌酮／舒巴坦、阿米卡星、头孢他啶、环丙沙星、左旋氧氟沙星和哌拉西林的敏感率分别为85．1％、73．0％、73．7％、75．7％、61．9％、63．6％、66．1％和61．3％。结论铜绿假单胞菌多来自痰及咽拭子标本，并对多种抗菌药物的耐药率较高，多重耐性明显。临床应根据药敏结果合理选用抗菌药物，以减少耐药菌株产生和控制医院感染。

Abstract Objective To investigate the trend of drug resistance rate of Pseudomonas aeruginosa in Jiangmen from 2003 to 2007, for the guidance of rational use of antibacterials. Methods A statistic analysis for the specimen source and drug resistance condition to 921 isolates was conducted in retrospective manner. Results Among 921 strains 57.9%（533/921） come from sputum and throat mucus and 15.2%（140/921） from wound swab. The result of drug susceptibility showed that P. aeruginosa to Imipenem, Piperacillin/tazobactam, Cefoperazone/ sulbactam、 Amikacin, Ceftazidime, Ciprofloxacin, Levofloxacin and Piperacillin was determined. The percentages of susceptibility rate were as follows：85.1%, 73.0%, 73.7%, 75.7%, 61.9%, 63.6%, 66.1% and 61.3%.Conclusion Clinical isolates of Pseudomonas aeruginosa come from the sputum and throat mucus, but their resistant rates are rather high and multidrugresistant. In order to reduce the drug-resistance strains and control the infection of Pseudomonas aeruginosa, antibiotics should be used reasonably according to drug susceptibility testing clinically.