期刊文献+

溶血性尿毒症性综合征14例临床分析 被引量:1

Clinical analysis of 14 patients with hemolytic uremic syndrome
下载PDF
导出
摘要 目的探讨溶血性尿毒症性综合征(HUS)的病因及临床诊疗。方法分析我院近10年来14例HUS患者的临床资料。结果13例患者具备HUS的典型临床表现,包括溶血性贫血、血小板减少和急性肾衰竭。1例患者虽不具有HUS的典型临床表现,但肾活检病理显示为典型的HUS肾脏微血管病变。经过包括血液净化在内的综合治疗,9例患者获得临床治愈,5例患者死亡。结论该病诊断主要依据病史、临床表现及病理检查进行综合分析,早期改善肾衰竭、纠正重度贫血并积极进行抗凝是治疗关键。 Objective To investigate the etiology ,diagnosis and treatment of hemolytic uremic syndrome. Methods The clinical dates were gleaned and analyzed in 14 patients with hemolytic uremic syndrome ,admitted in our hospital in the last 10 years. Results 13 ofthese patients have the typical clinical situation of hemolytic uremic syndrome,including microvascular hemolytic anemia, thrombocyt openia and acute renal failure. 1 of these patients has no the typical clinical situation of hemolytic uremic syndrome, but the pathological result of renal biopsy showed typical pathological change of hemolytic uremic syndrome in renal microangium. After comprehensive treatment ,including blood purification, 9 patients reached the clinical curing while another 5 patients died. Conclusions The diagnosis of hemolytic uremic syndrome mostly depends on the comprehensive analysis of pathography, clinical condition and pathological changes. The early improvement of renal failure, severe anemia and application of anticoagulant should be included as critical therapy for patients with hemolytic uremic syndrome.
出处 《临床肾脏病杂志》 2008年第5期215-217,共3页 Journal Of Clinical Nephrology
关键词 溶血性尿毒症性综合征 诊断 治疗 Hemolytic uremic syndrome Diagnosis Treatment
  • 相关文献

参考文献10

  • 1Geo JN. How I treat patients with thrombocytopenic purpura he molytic uremic syndrome. Blood, 2000,96 : 1223-1229.
  • 2Yoshioka K, Yagi K, Moriguchi N, et al. Clinical features and treatment of Children with hemolytic uremic syndrome caused by entero hemorrhagic Escherichia Coli O157: H7infection : experience of an out break in Sakai City. Pediatrint, 1999. 41:223-227.
  • 3Kaplan BS, Cleary TG. Recent advances in understanding the pathogenesis of the uremic syndrome. Pediatr Nephrol, 1990,4: 276-283.
  • 4Karmali MA, Petric M, Lim C, et al. The association between idiopathic hemolytic uremicsyndrome and infection by verotoxinproducing Esche-richia coll. J Infect Dis , 2004,189: 556-563.
  • 5Melnyk AM, Solez K, Kjellstrand CM. Adult hemolytic uremic syndrome:A review of 37 cases. Arch Intern Med , 1995, 155: 2077-2084.
  • 6Siegler RL. The hemolytic uremic syndrome. Pediat Clin North Am, 1995.42 : 1505-1529.
  • 7Conlon PT, Howell DN, Macik G, et al. The renal manifestations and outcome of thrombocytopenic purpura-hemolytic uremic syndrome in adults. Nephrol Dial Transplant, 1995,10: 1189-1193.
  • 8Bergstein JM,Riley M,Bang NU. Role of plasminogen activator inhibitor type 1 in the pathogenesis and outcome of the hemolytic uremic syndrome. N Engl J Med, 1992,327:755-759.
  • 9Ruggenenti P , Remuzzi G. Pathophysiology and management of thrombotic microangiopathies. J Nephrol , 1998 , 11 : 300-310.
  • 10Renaud C, Niaudet P, Gagnadoux MF. et al. Hemolytic uremic syndrome:Prognostic factors in children over 3 years of age. Pediatr Nephrol, 1995,9:24-25.

同被引文献8

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部