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皮肤致敏体外替代方法研究进展 被引量：2

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摘要 免疫分子生物学的极大发展和动物福利呼声的日益高涨,使体外评价化学物致敏性成为毒理学研究的热点。目前,通过体外培养细胞检测其表面因子和某些蛋白质的表达来判定受试物是否为致敏物为主要研究内容。其中皮肤致敏体外替代方法主要包括人源单细胞株培养、平行试验、体外皮肤重建系统等。
作者 王辉 魏雪涛
机构地区 北京大学医学部公共卫生学院
出处 《国外医学（卫生学分册）》 2008年第4期249-254,共6页 Foreign Medical Sciences(Section of Hygiene)
基金 国家十一五科技支撑项目(2006BAK02A02) 北京市自然科学基金项目(7082054)
关键词 接触过敏性皮炎 体外替代 致敏物 刺激物
分类号 R392-33 [医药卫生—免疫学] R99 [医药卫生—毒理学]
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参考文献24

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同被引文献20

  • 1梁震,黄耀师,梁虓,张博,袁建华,马洪英.SUZUTOS豚鼠皮肤致敏GLP试验研究[J].动物医学进展,2008,29(S1):3-4. 被引量：3
  • 2戴宇飞,李海山,孙耀峰,冷曙光,牛勇,程娟,张林媛,郑玉新.代谢活化在三氯乙烯对小鼠致敏及肝毒性中的作用[J].中国药理学与毒理学杂志,2005,19(5):378-382. 被引量：10
  • 3李启富,刘琳,喻荣珍,褚芳,田泽敏.2,4-二硝基氯苯在致敏试验中剂量方法的探讨[J].毒理学杂志,2006,20(6):401-401. 被引量：2
  • 4Zhai H, Maibach H I. Anti - irritants agents for the treat- ment of irritant contact dermatitis: clinical and patent perspective [ J ]. Recent Pat Inflamm Allergy Drug Dis- coy, 2012,6(3) :169 - 185.
  • 5Li T, Chen H, Wei N, et al. Anti - inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity in vivo [ J ]. Int Immunopharmacol, 2012,12(1) :144 - 150.
  • 6Smedley J. Concise guidance: diagnosis, management and prevention of occupational contact dermatitis [ J ]. Clin Med, 2010,10 ( 5 ) : 487 - 490.
  • 7Westphal G A, Schnuch A, Moessner R, et al. Cytokine gene polymorphisms in allergic contact dermatitis [ J l- Contact Dermatitis, 2003,48 (2) :93 - 98.
  • 8Hopkins J E, Naisbitt D J, Kitteringham N R, et al. Se- lective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization [Jl. ChemResToxieol, 2005,18(2) :375 -381.
  • 9Valero A, Pereira C, Loureiro C, et al. Interrelationship Between Skin Sensitization, Rhinitis, and Asthma in Patients With Allergic hinitis: A Study of Spain and Portugal [ J ]. J Invest Allergol Clini lmmunol, 2009,19:167 - 172.
  • 10Anderson SE, Siegel PD, Meade BJ. The LLNA : a brief review of recen- tadvances and limitations[ J]. J Allergy (Cairo) ,2011:1 - 10.

引证文献2

二级引证文献7

国外医学（卫生学分册）
2008年 第4期

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