安宫牛黄丸防治肝癌经动脉化疗栓塞术后综合征

Clinical Observation on the Curative Effect of Angong Niuhuang Wan in Hepatocellular Carcinoma Patients with Postoperative Syndrome Group after Transcatheter Arterial Chemoembolization

目的:观察安宫牛黄丸防治肝癌经动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)后综合征的疗效并探讨其可能作用机制。方法:采用随机对照方法,将60例原发性肝癌患者分为治疗组(n=30)和对照组(n=30);两组在TACE后均予常规对症处理;治疗组在TACE术后予安宫牛黄丸,连续用药1周,分析观察两组临床症状、肿瘤坏死因子α(TNF-α)等变化。结果:安宫牛黄丸可显著缓解肝癌栓塞后综合征相关恶心、呕吐、发热、疼痛等症状,并且治疗组TNF-α下降更明显。结论:安宫牛黄丸可有效防治TACE检塞后综合征,降低TNF-α可能是其作用机制之一。

Objective：To evaluate the curative effect of Angong Niuhuang wan in hepatocellular carcinoma patients with postoperative syndrome group after transcatheter arterial chemoembolization and to discuss the probable mechanism.Methods：Sixty Hepatocellular Carcinoma patients were divided in the treatment group（n=30） and the control group（n=30） conducted with random control.Regular therapeutic scheme were performed after the TACE operation,with the application of the Angong Niuhuang Wan in the treatment group for one week.The clinical symptoms and the levels of the TNF-α were collected in both groups.Results：The application with the Angong-Niuhuang-Wan after the TACE might take the effect of minimizing damage of the nausea and vomiting,fever and pain,and The application with the Angong-Niuhuang-Wan might decrease the TNF-α levels.Conclusion：The postoperative syndrome group after the TACE might be alleviated by the application with the Angong Niuhuang Wan,alleviating the TNF-α level might be one of the probable mechanisms.