乳腺癌组织中期因子的表达及其临床意义

Clinical Significance of Midkine Expression in Breast Cancer

目的:探讨乳腺癌组织中期因子表达的临床意义。方法:用免疫组化方法检测乳腺癌病理标本中期因子的表达,结合病例随访临床资料,分析其临床意义。结果:64例乳腺癌病例获得完整随访资料,79.7%(51/64例)患者中期因子表达阳性,中期因子表达检测率与肿瘤分期呈正相关(P<0.05)、中期因子的检出与乳腺癌发生远处转移密切相关(P<0.05)。结论:中期因子与乳腺癌的进展存在一定相关性,检测中期因子的表达对乳腺癌的诊断和治疗有参考价值。

Objective：To analysis the relationship of midkine expression and the clinical data in breast cancer.Methods：The follow up clinical data of 64 breast cancer patients who had operation during 1999 to 2001 were obtained,their paraffin wax specimen were detected for midkine expression by immunohistochemistry.The relationship of midkine expression and those clinical data were analyses.Results：Midkine expression were detected in 79.7%（51/64）patients,the positive result of midkine detection had significant relationship to the stage of breast cancer（P〈0.05） and metastasis（P〈0.05）.Conclusion：It was found that midkine expression had certain relationship to the advance of breast cancer,so midkine detection may give us knowledge in diagnosis and treatment of breast cancer.