尿路感染细菌分布及大肠埃希菌耐药性分析

Distribution of Bacteria in Urinary Tract Infection and Analysis of Drug Resistance of Escherichia coli

目的分析尿路感染的病原菌分布及主要致病菌大肠埃希菌的耐药性,为临床合理使用抗菌药物提供科学依据。方法统计2007年本院尿液标本中分离的各种病原菌,并对大肠埃希菌药敏试验结果进行分析。结果尿路感染病原菌以大肠埃希菌为主,占40.31%,其次为真菌和肠球菌。大肠埃希菌对氨苄西林、头孢噻吩、萘啶酸、替卡西林的耐药率均在90%以上,对头孢西丁、呋喃妥因的耐药率小于10%,对亚胺培南则全部敏感。结论尿路感染主要致病菌为大肠埃希菌,应及时检测病原菌及其耐药情况,合理使用抗菌药物。

Objective To investigate the distribution of pathogens and resistance of Escherichia coli with urinary tract infection for the guidance of rational use of antibiotics. Methods To analyse the distribution of bacteria isolated from urine in our hospital and study the antimicrobial resistance of strains of E. coll. Results The most common pathogens in urinary tract infection were E. coli（40.31%）, next were Fungi and Enterococcus. For the antibiotic ampicillin, cefalotin, nalidixic acid and ticarcillin, the rates of resistance of E. coli were more than 90%. For the antibiotic cefoxitin and nitrofurantoin, the rates of resistance of E. coli were less than 10%. All of E. coli strains were sensitive to impenem. Conclusion E. coli is still the primary urinary pathogen in our hospital,the clinics should choose the appropriate antibiotic agents according to the culture and in vitro susceptibility of bacteria.