新霉素A、B及其衍生物抗HIV作用的研究

Research on the Anti-HIV Effects of Neomycin and Its Derivatives

人类免疫缺陷病毒(human immunodeficiency virus,HIV)自20世纪80年代被发现以来在全世界范围内迅速蔓延,严重地威胁到人类的健康,故研制高效、低毒的抗HIV药物迫在眉睫。本文综述了新霉素A、B及其衍生物作用于HIV的3个不同途径,包括:(1)与HIV RNA上的TAR和RRE结合;(2)与gp120-gp41竞争性地和CD4,CXCR4\CCR5结合;(3)作用于HIV的171-merψ-RNA。此外,还针对这3个不同途径分别阐述了其相应的作用机制。新霉素及其衍生物抗HIV作用的研究结果为抗HIV药物的研究提供了更多的研究方向及可借鉴的研究方法。

Human immunodeficiency virus （HIV） has been spreading throughout the world rapidly since it was found in the 1980s and poses a huge threat to human health. Therefore, it is urgent to develop anti-HIV drugs demonstrating good efficacy and least toxicity. This review paper summarized three pathways by which neomycin A, B and their derivatives bind to HIV, including binding to TAR （trans-acting responsive sequence） or RRE （rev responsive element）of HIV RNA, competing with gp120 - gp41 to combine with CD4 or CXCR4／CCR5, acting on 171-mer φ -RNA of HIV. Furthermore, the corresponding mechanisms of these three pathways were also elucidated in detail.